منابع مشابه
Mechanism of eve stripe formation
In this paper we analyze the formation of stripes of expression of the pair-rule gene eve. We identify detailed mechanisms which control the formation of stripes 2-5. Each stripe is formed as a result of generalized activation by bcd and ubiquitous transcription factors combined with localized repression by gap genes. Each of the eight stripe borders of these four stripes is shown to be under t...
متن کاملTranscriptional bursting in Drosophila development: Stochastic dynamics of eve stripe 2 expression
Anterior-posterior (AP) body segmentation of the fruit fly (Drosophila) is first seen in the 7-stripe spatial expression patterns of the pair-rule genes, which regulate downstream genes determining specific segment identities. Regulation of pair-rule expression has been extensively studied for the even-skipped (eve) gene. Recent live imaging, of a reporter for the 2nd eve stripe, has demonstrat...
متن کاملFunctional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change.
Experimental investigations of eukaryotic enhancers suggest that multiple binding sites and trans-acting regulatory factors are often required for wild-type enhancer function. Genetic analysis of the stripe 2 enhancer of even-skipped (eve), an important developmental gene in Drosophila, provides support for this view. Given the importance of even-skipped expression in early Drosophila developme...
متن کاملThe eve stripe 2 enhancer employs multiple modes of transcriptional synergy.
Previous studies have provided a detailed model for the regulation of even-skipped (eve) stripe 2 expression in the Drosophila embryo. The bicoid (bcd) regulatory gradient triggers the expression of hunchback (hb); these work synergistically to activate the stripe in the anterior half of the embryo, bcd also coordinates the expression of two repressors, giant (gt) and Kruppel (Kr), which define...
متن کاملJahn-Teller mechanism of stripe formation in doped layered La(2-x)Sr(x)NiO4 nickelates.
We introduce an effective model for e(g) electrons to describe quasi-two-dimensional layered La(2-x)Sr(x)NiO(4) nickelates and study it using correlated wavefunctions on 8 × 8 and 6 × 6 clusters. The effective Hamiltonian includes the kinetic energy, on-site Coulomb interactions for e(g) electrons (intraorbital U and Hund's exchange J(H)) and the coupling between e(g) electrons and Jahn-Teller ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 1995
ISSN: 0925-4773
DOI: 10.1016/0925-4773(94)00310-j